Hostname: page-component-848d4c4894-x5gtn Total loading time: 0 Render date: 2024-06-02T12:35:30.962Z Has data issue: false hasContentIssue false
  • English
  • Français

Influence of the products of phospholipolysis of phosphatidylcholine on micellar solubilization of fatty acids in the presence of bile salts

Published online by Cambridge University Press:  25 March 2008

A. K. Lough  and
A. Smith
A. K. Lough
Affiliation:
Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
A. Smith
Affiliation:
Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. The solubility of fatty acids in aqueous solutions containing bile salts and lysolecithin at pH values between 2.0 and 7.4 was studied. Both the 1-acyl and 2-acyl isomers of lysolecithin increased the solubility of fatty acids to the same extent, the order of solubility being linoleic > oleic > elaidic > palmitic > stearic.

2. The influence of the products of phospholipolysis of lecithin on palmitic acid solubility was determined. On a molar basis, lysolecithin was more effective than were bile salts in promoting the solubilization of the fatty acid.

3. In bile salt solutions in which the phospholipid concentration was constant on a molar basis, the solubility of palmitic acid decreased linearly with the progressive replacement of lecithin by lysolecithin. Palmitic acid was solubilized to the same extent on replacing lecithin with lysolecithin on a constant weight basis.

4. In bile salt solution containing lysolecithin and oleic acid in equimolar amounts, the solubility of palmitic acid was similar to that in bile salt solutions containing lecithin in equivalent proportion.

5. The results are discussed in relation to the action of phospholipolytic activity on the intestinal absorption of fatty acids in sheep.

Type
Papers on General Nutrition
Information
British Journal of Nutrition , Volume 35 , Issue 1 , January 1976 , pp. 89 - 96
Copyright
Copyright © The Nutrition Society 1976

References

Arienti, G., Leat, W. M. F. & Harrison, F. A. (1975). Q. Jl exp. Physiol. 60, 15.CrossRefGoogle Scholar
Freeman, C. P. (1969). Br. J. Nutr. 23, 249.CrossRefGoogle Scholar
Heath, T. J. & Hill, L. N. (1969). Aust. J. biol. Sci. 22, 1015.CrossRefGoogle Scholar
Heath, T. J. & Morris, B. (1963). Br. J. Nutr. 17, 465.Google Scholar
Lawrence, A. S. C. (1961 a). In Surface Activity and Detergency, p. 158 [Durham, K., editor]. London: Macmillan.Google Scholar
Lawrence, A. S. C. (1961 b). Chemy Ind. p. 1764.CrossRefGoogle Scholar
Leat, W. M. F. & Harrison, F. A. (1969). Q. Jl exp. Physiol. 54, 187.CrossRefGoogle Scholar
Lennox, A. M. & Garton, G. A. (1968). Br. J. Nutr. 22, 247.CrossRefGoogle Scholar
Lennox, A. M., Lough, A. K. & Garton, G. A. (1968). Br. J. Nutr. 22, 237.CrossRefGoogle Scholar
Long, C. & Penny, I. F. (1957). Biochem. J. 65, 382.Google Scholar
Lough, A. K. (1970). In Physiology of Digestion and Metabolism in the Ruminant, p. 519 [Phillipson, A. T., editor]. Newcastle upon Tyne: Oriel Press.Google Scholar
Neiderhiser, P. W. & Roth, H. P. (1972). Biochim. biophys. Acta 270, 407.CrossRefGoogle Scholar
Nilsson, A. (1968). Biochim. biophys. Acta 152, 379.CrossRefGoogle Scholar
Savary, P. (1966). Biochim. biophys. Acta 125, 328.CrossRefGoogle Scholar
Scott, A. M. & Lough, A. K. (1971). Br. J. Nutr. 25, 307.Google Scholar
Scow, R. O., Stein, Y. & Stein, O. (1967). J. biol. Chem. 242, 4919.CrossRefGoogle Scholar
Slotboom, A. J., De Haas, G. H. & Van Deenen, L. L. M. (1967). Chem. Phys. Lipids 1, 317.CrossRefGoogle Scholar
Smith, A. (1974). Aspects of micellar solubilization of fatty acids by biliary components in relation to lipid digestion in the sheep. PhD Thesis, University of Aberdeen.Google Scholar
Smith, A., Anderson, L. J. & Lough, A. K. (1973). Chemy Ind. p. 484.Google Scholar
Smith, A. & Lough, A. K. (1973). Proc. Nutr. Soc. 32, 62A.Google Scholar
Smith, A. & Lough, A. K. (1976). Br.J. Nutr. 35, 77.Google Scholar