Flavone C-glycosides from the Leaves of Lophatherum gracile and Their In Vitro Antiviral Activity

 

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Abstract

Four new flavone C-glycosides, luteolin 6-C-α-L-arabinopyranosyl-7-O-β-D-glucopyranoside (1), apigenin 6-C-β-D-galactopyranosiduronic acid (1 → 2)-α-L-arabinopyranoside (2), luteolin 6-C-β-D-galactopyranosiduronic acid (1 → 2)-α-L-arabinopyranoside (3), and luteolin 6-C-β-D-glucopyranosiduronic acid (1 → 2)-α-L-arabinofuranoside (4), along with three known ones, were isolated from the leaves of Lophatherum gracile. The structures of the new compounds were elucidated by extensive spectroscopic methods as well as acid hydrolysis. All the flavone glycosides isolated from this plant were screened for their in vitro antiviral activity against respiratory syncytial virus (RSV) with cytopathic effect (CPE) reduction assay, and several flavone 6-C-monoglycosides showed potent in vitro anti-RSV effect.

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1 These authors contributed equally to this work.

Prof. Dr. Wen-Cai Ye

Institute of Traditional Chinese Medicine & Natural Products
College of Pharmacy
Jinan University

No. 601 Huangpu Road West

510632 Guangzhou

P. R. China

Phone: +86 20 85 22 09 36

Fax: +86 20 85 22 15 59

Email: chywc@yahoo.com.cn

Prof. Dr. Yao-Lan Li

Institute of Traditional Chinese Medicine & Natural Products
College of Pharmacy
Jinan University

No. 601 Huangpu Road West

510632 Guangzhou

P. R. China

Phone: +86 20 85 22 17 28

Fax: +86 20 85 22 15 59

Email: tliyl@jnu.edu.cn

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