Towards tailoring hydrophobic interaction with uranyl(vi) oxygen for C–H activation

Abstract

Bovine serum albumin (BSA) has a uranyl(VI) binding hotspot where uranium is tightly bound by three carboxylates. Uranyl oxygen is “soaked” into the hydrophobic core of BSA. Isopropyl hydrogen of Val is trapped near UO22+ and upon photoexcitation, C–H bond cleavage is initiated. A unique hydrophobic contact with “yl”-oxygen, as observed here, can be used to induce C–H activation.

Graphical abstract: Towards tailoring hydrophobic interaction with uranyl(vi) oxygen for C–H activation

Supplementary files

Article information

Article type
Communication
Submitted
05 Mar 2024
Accepted
25 Mar 2024
First published
25 Mar 2024
This article is Open Access
Creative Commons BY license

Chem. Commun., 2024, Advance Article

Towards tailoring hydrophobic interaction with uranyl(VI) oxygen for C–H activation

S. Tsushima, J. Kretzschmar, H. Doi, K. Okuwaki, M. Kaneko, Y. Mochizuki and K. Takao, Chem. Commun., 2024, Advance Article , DOI: 10.1039/D4CC01030B

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements