Solvent-free synthesis of chalcones using Mg(HSO4)2†
Abstract
An innovative synthetic pathway for the synthesis of chalcones is proposed using the chemical and environmental advantages of solvent-free chemistry. The protocol was used for the synthesis of different medicinally relevant chalcones, as well as of a variety of naturally occurring chalcones, as a greener alternative to the existing methods. Finally, the solvent-free method was applied to the synthesis of bioactive drugs, such as metochalcone and elafibranor. We were also able to optimize the solid-state conditions by exploring a variety of mechanochemical conditions, including ball milling, mechanical stirring, and an ‘endless-screw’ system, which can be promising from an industrial perspective.
- This article is part of the themed collection: RSC Sustainability: Highlight Mainland Europe 2023
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