Issue 21, 2023
From the journal:

Chemical Science

Enantioselective total syntheses of six natural and two proposed meroterpenoids from Psoralea corylifolia†

Xiao-Wei Chen,a   Zi-Chao Hou,a   Chi Chen,a   Ling-Hui Zhang,a   Meng-En Chena  and  Fu-Min Zhang ORCID logo *ab  

* Corresponding authors

a State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China
E-mail: zhangfm@lzu.edu.cn

b Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China

Abstract

The first enantioselective total syntheses of six natural and two proposed meroterpenoids isolated from Psoralea corylifolia have been achieved in 7–9 steps from 2-methylcyclohexanone. The current synthetic approaches feature a high level of synthetic flexibility, stereodivergent fashion and short synthetic route, thereby providing a potential platform for the preparation of numerous this-type meroterpenoids and their pseudo-natural products.

Graphical abstract: Enantioselective total syntheses of six natural and two proposed meroterpenoids from Psoralea corylifolia

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Article information

DOI
https://doi.org/10.1039/D3SC00582H
Article type
Edge Article
Submitted
02 Feb 2023
Accepted
01 May 2023
First published
02 May 2023
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2023,14, 5699-5704

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Enantioselective total syntheses of six natural and two proposed meroterpenoids from Psoralea corylifolia

X. Chen, Z. Hou, C. Chen, L. Zhang, M. Chen and F. Zhang, Chem. Sci., 2023, 14, 5699 DOI: 10.1039/D3SC00582H

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