Issue 10, 2023
From the journal:

Organic Chemistry Frontiers

Enantioselective total syntheses of (−)-cephalotaxine and (−)-amathaspiramide F through a key Ir/Cu dual catalysis†

Peng-Zhen Sheng,‡ac   Lu-Lu Li,‡bc   Hongbin Zhang, ORCID logo a   Kun Wei*c  and  Yu-Rong Yang ORCID logo *c  

* Corresponding authors

a Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Provincial Centre for Research and Development of Natural Products, School of Chemical Science and Technology, Yunnan University, Kunming, China

b School of Life Sciences, Yunnan University, Kunming, China

c State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China
E-mail: yangyurong@mail.kib.ac.cn, weikun@mail.kib.ac.cn

Abstract

A recently developed Ir/Cu dual catalysed allylation, which could efficiently provide excellent enantio- and diastereoselectivity in the construction of vicinal tertiary and N-substituted quaternary stereogenic centres in one step, is strategically utilised for the first time in the syntheses of two alkaloids—cephalotaxine and amathaspiramide F.

Graphical abstract: Enantioselective total syntheses of (−)-cephalotaxine and (−)-amathaspiramide F through a key Ir/Cu dual catalysis

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Article information

DOI
https://doi.org/10.1039/D3QO00233K
Article type
Research Article
Submitted
14 Feb 2023
Accepted
15 Apr 2023
First published
24 Apr 2023

Org. Chem. Front., 2023,10, 2532-2537

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Enantioselective total syntheses of (−)-cephalotaxine and (−)-amathaspiramide F through a key Ir/Cu dual catalysis

P. Sheng, L. Li, H. Zhang, K. Wei and Y. Yang, Org. Chem. Front., 2023, 10, 2532 DOI: 10.1039/D3QO00233K

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