Photocatalyzed hydroxyalkylation of N-heteroaromatics with aldehydes in the aqueous phase

Jun Xu; Li Liu; Zhao-Cheng Yan; Yang Liu; Long Qin; Ning Deng; Hua-Jian Xu

doi:10.1039/D3GC00162H

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Photocatalyzed hydroxyalkylation of N-heteroaromatics with aldehydes in the aqueous phase†

Jun Xu,

^a Li Liu,^a Zhao-Cheng Yan,^a Yang Liu,^a Long Qin,^a Ning Deng*^a and Hua-Jian Xu

*^a

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* Corresponding authors

^a School of Food and Biological Engineering, School of Chemistry and Chemical Engineering, Anhui Province Key Laboratory of Advance Catalytic Materials and Reaction Engineering, Hefei University of Technology, Hefei 230009, P. R. China
E-mail: hjxu@hfut.edu.cn, ndeng@hfut.edu.cn

Abstract

Hydroxyalkylated N-heteroaromatics are interesting scaffolds in a wide range of biologically active natural molecules. Herein, a photoredox-catalyzed hydroxyalkylation method for azole derivatives with aldehydes in the aqueous phase under an air atmosphere has been established. Furthermore, our catalytic system is also suitable for the alkylation of azole derivatives with alkanes. This methodology features eco-friendliness, requires no external additive and has good functional group compatibility.

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Article information

DOI: https://doi.org/10.1039/D3GC00162H
Article type: Communication
Submitted: 14 Jan 2023
Accepted: 15 Feb 2023
First published: 16 Feb 2023

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Green Chem., 2023,25, 2268-2273

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Photocatalyzed hydroxyalkylation of N-heteroaromatics with aldehydes in the aqueous phase

J. Xu, L. Liu, Z. Yan, Y. Liu, L. Qin, N. Deng and H. Xu, Green Chem., 2023, 25, 2268 DOI: 10.1039/D3GC00162H

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Green Chemistry

Photocatalyzed hydroxyalkylation of N-heteroaromatics with aldehydes in the aqueous phase†

Abstract

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Photocatalyzed hydroxyalkylation of N-heteroaromatics with aldehydes in the aqueous phase

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