Multidisciplinary approaches for enzyme biocatalysis in pharmaceuticals: protein engineering, computational biology, and nanoarchitectonics

Suhyeon Kim; Seongmin Ga; Hayeon Bae; Ronald Sluyter; Konstantin Konstantinov; Lok Kumar Shrestha; Yong Ho Kim; Jung Ho Kim; Katsuhiko Ariga

doi:10.1039/D3EY00239J

Multidisciplinary approaches for enzyme biocatalysis in pharmaceuticals: protein engineering, computational biology, and nanoarchitectonics

Suhyeon Kim,

^abc Seongmin Ga,

^bc Hayeon Bae,

^bc Ronald Sluyter,

^d Konstantin Konstantinov,

^a Lok Kumar Shrestha,

^ef Yong Ho Kim,

*^bcg Jung Ho Kim

*^a and Katsuhiko Ariga

*^eh

Author affiliations

* Corresponding authors

^a Institute for Superconducting and Electronic Materials, Australian Institute for Innovative Materials, University of Wollongong, Squires Way, North Wollongong, NSW 2500, Australia
E-mail: jhk@uow.edu.au

^b SKKU Advanced Institute of Nanotechnology (SAINT), Sungkyunkwan University (SKKU), 2066 Seobu-ro, Jangan-gu, Suwon, Gyeonggi-do 16419, Republic of Korea
E-mail: yhkim94@skku.edu

^c Department of Nano Science and Technology, Sungkyunkwan University (SKKU), Suwon, Republic of Korea

^d Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Northfields Avenue, Wollongong, NSW 2522, Australia

^e Research Center for Materials Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS), Tsukuba 305-0044, Japan
E-mail: ARIGA.Katsuhiko@nims.go.jp

^f Department of Materials Science, Faculty of Pure and Applied Sciences, University of Tsukuba, 1-1, Tennodai, 305-8573 Tsukuba, Ibaraki, Japan

^g Department of Nano Engineering, Sungkyunkwan University (SKKU), Suwon, Republic of Korea

^h Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa 277-8561, Japan

Abstract

Enzyme biocatalysis is reshaping pharmaceutical synthesis, offering sustainable and efficient pathways for drug discovery and production. This paradigm shift towards eco-friendly methodologies addresses concerns inherent in traditional chemical synthesis. Enzymes, celebrated for their precision and adaptability to mild conditions, are poised as ideal candidates for pharmaceutical applications. Their versatility facilitates the synthesis of diverse pharmaceutical compounds, ensuring precise drug design and minimizing environmental impact. The integration of multidisciplinary approaches, including protein engineering, computational biology, and nanoarchitectonics, holds the potential to propel enzyme biocatalysis even further. Protein engineering utilizes directed evolution and rational design to customize enzymes, enhancing their stability and efficacy. Computational biology aids in deciphering enzymatic mechanisms, while nanoarchitectonics introduces innovative enzyme integration strategies into continuous flow systems. This comprehensive review explores how these multidisciplinary approaches can revolutionize pharmaceutical research and production. The synergy among these disciplines promises to expedite pharmaceutical processes, promote sustainability, optimize efficiency, and elevate precision—aligning perfectly with the evolving requirements of the pharmaceutical industry.

This article is part of the themed collection: EES Catalysis Recent Review Articles

Article information

https://doi.org/10.1039/D3EY00239J

Article type

Review Article

Submitted

02 Oct 2023

Accepted

27 Oct 2023

First published

28 Oct 2023

This article is Open Access

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EES. Catal., 2024,2, 14-48

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Multidisciplinary approaches for enzyme biocatalysis in pharmaceuticals: protein engineering, computational biology, and nanoarchitectonics

S. Kim, S. Ga, H. Bae, R. Sluyter, K. Konstantinov, L. K. Shrestha, Y. H. Kim, J. H. Kim and K. Ariga, EES. Catal., 2024, 2, 14 DOI: 10.1039/D3EY00239J

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EES Catalysis

Multidisciplinary approaches for enzyme biocatalysis in pharmaceuticals: protein engineering, computational biology, and nanoarchitectonics

Abstract

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Multidisciplinary approaches for enzyme biocatalysis in pharmaceuticals: protein engineering, computational biology, and nanoarchitectonics

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