Understanding the mechanism by which Gd(III) coiled coils achieve magnetic resonance relaxivity – a study into the water coordination chemistry

S. L. Newton; A. Franke; A. Zahl; G. Molinaro; A. Kenwright; D. J. Smith; I. Ivanovic-Burmazovic; M. M. Britton; A. F. A. Peacock

doi:10.1039/D3DT02909C

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Understanding the mechanism by which Gd(iii) coiled coils achieve magnetic resonance relaxivity – a study into the water coordination chemistry†

S. L. Newton,^ab A. Franke,^cd A. Zahl,^c G. Molinaro,^a A. Kenwright,

^e D. J. Smith,^f I. Ivanovic-Burmazovic,*^cd M. M. Britton

*^a and A. F. A. Peacock

*^a

Author affiliations

* Corresponding authors

^a School of Chemistry, University of Birmingham, Edgbaston, UK
E-mail: m.m.britton@bham.ac.uk, a.f.a.peacock@bham.ac.uk

^b PSIBS, School of Chemistry, University of Birmingham, Edgbaston, UK

^c Department Chemie und Pharmazie, Universität Erlangen-Nürnberg, Erlangen, Germany

^d Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377 München, Germany

^e School of Chemistry, Durham University, Durham, UK

^f School of Mathematics, University of Birmingham, Edgbaston, UK

Abstract

A class of Gd(III) coiled coils achieve high MRI relaxivity, in part due to their slow rotational correlation time. However, extending their length is unable to further enhance performance, as the mechanism by which relaxivity is achieved is dominated by the presence of three inner sphere waters in rapid exchange, through an associative mechanism.

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DOI: https://doi.org/10.1039/D3DT02909C
Article type: Communication
Submitted: 06 Sep 2023
Accepted: 23 Oct 2023
First published: 24 Oct 2023
This article is Open Access

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Dalton Trans., 2023,52, 15665-15668

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Understanding the mechanism by which Gd(III) coiled coils achieve magnetic resonance relaxivity – a study into the water coordination chemistry

S. L. Newton, A. Franke, A. Zahl, G. Molinaro, A. Kenwright, D. J. Smith, I. Ivanovic-Burmazovic, M. M. Britton and A. F. A. Peacock, Dalton Trans., 2023, 52, 15665 DOI: 10.1039/D3DT02909C

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Understanding the mechanism by which Gd(iii) coiled coils achieve magnetic resonance relaxivity – a study into the water coordination chemistry†

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Understanding the mechanism by which Gd(III) coiled coils achieve magnetic resonance relaxivity – a study into the water coordination chemistry

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