Photonic Si microwell architectures for rapid antifungal susceptibility determination of Candida auris

Christopher Heuer; Xin Jiang; Gali Ron; Orna Ternyak; Thomas Scheper; Janina Bahnemann; Ester Segal

doi:10.1039/D3CC04446G

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Photonic Si microwell architectures for rapid antifungal susceptibility determination of Candida auris†

Christopher Heuer,

^abc Xin Jiang,

^a Gali Ron,^a Orna Ternyak,^d Thomas Scheper,^b Janina Bahnemann

^c and Ester Segal

*^a

Author affiliations

* Corresponding authors

^a Department of Biotechnology and Food Engineering, Technion – Israel Institute of Technology, Haifa, Israel
E-mail: esegal@technion.ac.il

^b Institute of Technical Chemistry, Leibniz University Hannover, Hannover 30167, Germany

^c Institute of Physics, University of Augsburg, Augsburg 86159, Germany

^d Micro- and Nanofabrication and Printing Unit, Technion – Israel Institute of Technology, Haifa, Israel

Abstract

We present the application of a photonic silicon chip-based optical sensor system for expeditious and phenotypic antifungal susceptibility testing. This label-free diagnostic assay optically monitors the growth of Candida auris at varying antifungal concentrations on a microwell-structured silicon chip in real-time, and antifungal susceptibility is detected within 6 h, four times faster than in the current gold standard method.

This article is part of the themed collection: Sensors for Health

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Article information

DOI: https://doi.org/10.1039/D3CC04446G
Article type: Communication
Submitted: 07 Sep 2023
Accepted: 18 Dec 2023
First published: 27 Dec 2023
This article is Open Access

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Chem. Commun., 2024,60, 1305-1308

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Photonic Si microwell architectures for rapid antifungal susceptibility determination of Candida auris

C. Heuer, X. Jiang, G. Ron, O. Ternyak, T. Scheper, J. Bahnemann and E. Segal, Chem. Commun., 2024, 60, 1305 DOI: 10.1039/D3CC04446G

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Chemical Communications

Photonic Si microwell architectures for rapid antifungal susceptibility determination of Candida auris†

Abstract

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Photonic Si microwell architectures for rapid antifungal susceptibility determination of Candida auris

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