SCHEDULED MAINTENANCE
Secondary-sphere preorganization enables nickel-catalyzed nitrile hydroboration†
Medina
Afandiyeva, 
‡a
Xijue
Wu,
‡a
William W.
Brennessel,
a
Abhishek A.
Kadam
a
and
C. Rose
Kennedy
*a
‡a
Xijue
Wu,
‡a
William W.
Brennessel,
a
Abhishek A.
Kadam
a
and
C. Rose
Kennedy
*a
Abstract
Herein, we describe nickel-catalyzed nitrile hydroboration with pinacolborane, wherein a tethered NHC–pyridonate ligand enables efficient catalysis (5 mol% [Ni], ≤6 h reaction time) at room temperature. Mechanistic studies, including isolation of the catalytically relevant intermediates, shed light on the cooperative role of the ligand in activating both reagents simultaneously.
- This article is part of the themed collection: 2023 Emerging Investigators
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