Issue 70, 2023
From the journal:

Chemical Communications

Phospholipid headgroup composition modulates the molecular interactions and antimicrobial effects of sulfobetaine zwitterionic detergents against the “ESKAPE” pathogen Pseudomonas aeruginosa†

Kira L. F. Hilton,a   Howard Tolley,b   Jose L. Ortega-Roldan, ORCID logo a   Gary S. Thompson, ORCID logo a   J. Mark Sutton,bc   Charlotte K. Hind*b  and  Jennifer R. Hiscock ORCID logo *a  

* Corresponding authors

a Division of Natural Sciences, University of Kent, Canterbury, UK
E-mail: J.R.Hiscock@Kent.ac.uk

b UKHSA, Science Group, Manor Farm Road, Salisbury, UK
E-mail: Charlotte.Hind@UKHSA.gov.uk

c Institute of Pharmaceutical Sciences, School of Cancer & Pharmaceutical Sciences King's College London, UK

Abstract

We determine the efficacy for three known structurally related, membrane active detergents against multidrug resistant and wild type strains of Pseudomonas aeruginosa. Accessible solution state NMR experiments are used to quantify phospholipid headgroup composition of the microbial membranes and to gain molecular level insight into antimicrobial mode of action.

Graphical abstract: Phospholipid headgroup composition modulates the molecular interactions and antimicrobial effects of sulfobetaine zwitterionic detergents against the “ESKAPE” pathogen Pseudomonas aeruginosa

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Article information

DOI
https://doi.org/10.1039/D3CC02320F
Article type
Communication
Submitted
12 May 2023
Accepted
03 Aug 2023
First published
10 Aug 2023
This article is Open Access
Creative Commons BY license

Chem. Commun., 2023,59, 10504-10507

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Phospholipid headgroup composition modulates the molecular interactions and antimicrobial effects of sulfobetaine zwitterionic detergents against the “ESKAPE” pathogen Pseudomonas aeruginosa

K. L. F. Hilton, H. Tolley, J. L. Ortega-Roldan, G. S. Thompson, J. M. Sutton, C. K. Hind and J. R. Hiscock, Chem. Commun., 2023, 59, 10504 DOI: 10.1039/D3CC02320F

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