Development of light-induced disruptive liposomes (LiDL) as a photoswitchable carrier for intracellular substance delivery

Taichi Tsuneishi; Keiichi Kojima; Fumika Kubota; Hideyoshi Harashima; Yuma Yamada; Yuki Sudo

doi:10.1039/D3CC02056H

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Development of light-induced disruptive liposomes (LiDL) as a photoswitchable carrier for intracellular substance delivery†

Taichi Tsuneishi,^a Keiichi Kojima,^ab Fumika Kubota,^c Hideyoshi Harashima,

^c Yuma Yamada

^c and Yuki Sudo

*^ab

Author affiliations

* Corresponding authors

^a Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan
E-mail: sudo@okayama-u.ac.jp

^b Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan

^c Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan

Abstract

Light-driven inward proton pump rhodopsin RmXeR was embedded in pH-sensitive liposomes. Substance release from the proteoliposomes was observed following light illumination both in vitro and in cells, indicating the successful production of light-induced disruptive liposomes (LiDL). Thus, LiDL is a photoswitchable carrier utilized for intracellular substance delivery.

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Article information

DOI: https://doi.org/10.1039/D3CC02056H
Article type: Communication
Submitted: 28 Apr 2023
Accepted: 23 May 2023
First published: 23 May 2023
This article is Open Access

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Chem. Commun., 2023,59, 7591-7594

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Development of light-induced disruptive liposomes (LiDL) as a photoswitchable carrier for intracellular substance delivery

T. Tsuneishi, K. Kojima, F. Kubota, H. Harashima, Y. Yamada and Y. Sudo, Chem. Commun., 2023, 59, 7591 DOI: 10.1039/D3CC02056H

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Chemical Communications

Development of light-induced disruptive liposomes (LiDL) as a photoswitchable carrier for intracellular substance delivery†

Abstract

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Development of light-induced disruptive liposomes (LiDL) as a photoswitchable carrier for intracellular substance delivery

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