Issue 51, 2023
From the journal:

Chemical Communications

Integrated separation and detection of exosomes via a label-free magnetic SERS platform†

Lingfei Han, ORCID logo ‡ab   Chengcheng Zhu,‡a   Zheng Tan,‡a   Jin Wang,a   Xuewei Liao,*a   Xing-Hua Xia ORCID logo c  and  Chen Wang ORCID logo *ac  

* Corresponding authors

a College of Chemistry and Materials Science and Analytical & Testing Center, Nanjing Normal University, Nanjing 210023, China
E-mail: wangchen@njnu.edu.cn

b Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 211198, China

c State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University, Nanjing 210023, China

Abstract

A label-free magnetic surface enhanced Raman scattering (SERS) platform was constructed, which was composed of superparamagnetic Fe3O4 nanoparticles as cores for separation and Au layers as shells for label-free SERS detection. Our method could effectively distinguish exosomes from different cell sources for cancer diagnosis and showed high sensitivity and specificity within a 95% confidence interval. As a low-cost and efficient exosome analysis method, the designed integrated platform for separation and detection has promising applicability in clinical diagnostics.

Graphical abstract: Integrated separation and detection of exosomes via a label-free magnetic SERS platform

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Supplementary files

Article information

DOI
https://doi.org/10.1039/D3CC01530K
Article type
Communication
Submitted
29 Mar 2023
Accepted
23 May 2023
First published
29 May 2023

Chem. Commun., 2023,59, 7967-7970

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Integrated separation and detection of exosomes via a label-free magnetic SERS platform

L. Han, C. Zhu, Z. Tan, J. Wang, X. Liao, X. Xia and C. Wang, Chem. Commun., 2023, 59, 7967 DOI: 10.1039/D3CC01530K

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