SiO2@Au nanoshell-assisted laser desorption/ionization mass spectrometry for coronary heart disease diagnosis†
*a
Abstract
Cardiovascular diseases have threatened human health, amongst which coronary heart disease (CHD) is the third most common cause of death. CHD is considered to be a metabolic disease; however, there is little research on the CHD metabolism. Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) has enabled the development of a suitable nanomaterial that can be used to obtain considerable high-quality metabolic information without complex pretreatment of biological fluid samples. This study combines SiO2@Au nanoshells with minute plasma to obtain metabolic fingerprints of CHD. The thickness of the SiO2@Au shell was also optimized to maximize the laser desorption/ionization effect. The results demonstrated 84% sensitivity at 85% specificity for distinguishing CHD patients from controls in the validation cohort.
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