Synthesis, characterization and anticancer activities of Zn2+, Cu2+, Co2+ and Ni2+ complexes involving chiral amino alcohols

Q. Umar; Y. H. Huang; A. Nazeer; H. Yin; J. C. Zhang; M. Luo; X. G. Meng

doi:10.1039/D2RA05576G

Synthesis, characterization and anticancer activities of Zn²⁺, Cu²⁺, Co²⁺ and Ni²⁺ complexes involving chiral amino alcohols†

Q. Umar,

‡^a Y. H. Huang,‡^a A. Nazeer,

^a H. Yin,^a J. C. Zhang,

^a M. Luo

*^a and X. G. Meng

*^b

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* Corresponding authors

^a Department of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei, P.R. China
E-mail: luomei@pku.edu.cn, mengxianggao@ccnu.edu.cn

^b College of Chemistry, Central China Normal University, Wuhan, P.R. China

Abstract

Seven new metal coordination complexes, [NiC₁₅H₄₃N₅O₁₁] (I), [Co₃C₃₆H₉₈N₆O₆] (II), [CuC₁₄H₃₂N₂O₆] (III), [Cu₂C₃₂H₄₃Cl₂N₂O₁₃] (IV), [Zn₂C₂₄H₃₂Cl₃N₃O₃] (V), [Co₃C₄₈H₆₆Cl₆N₆O₆] (VI), and [Zn (C₁₈H₄₅N₃O₃] (VII), have been synthesized from some direct reactions of amino-alcoholic ligands with metal salts in anhydrous methanol or ethanol medium. All the crystals of these seven complexes are crystallized in the chiral space groups (P2₁2₁2₁ for (I), (IV), (VI) and (VII); P2₁ for (III) and (V); and C₂ for (II), respectively). Their characteristic peaks were analyzed and assigned by FTIR, NMR, and UV–Vis and elemental analysis techniques. The anticancer activities of amino alcohol complexes (I)–(VII) showed cytotoxic effects against the human tumour cell line A549; among them, complex (V) showed the best activity with an IC₅₀ value of 17.8. The higher biological activity should be related to its di-nuclear zinc(II) unit in which one zinc is only four-coordinated by four small chloride anions.

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DOI: https://doi.org/10.1039/D2RA05576G
Article type: Paper
Submitted: 05 Sep 2022
Accepted: 24 Oct 2022
First published: 09 Nov 2022
This article is Open Access

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RSC Adv., 2022,12, 32119-32128

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Synthesis, characterization and anticancer activities of Zn²⁺, Cu²⁺, Co²⁺ and Ni²⁺ complexes involving chiral amino alcohols

Q. Umar, Y. H. Huang, A. Nazeer, H. Yin, J. C. Zhang, M. Luo and X. G. Meng, RSC Adv., 2022, 12, 32119 DOI: 10.1039/D2RA05576G

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Synthesis, characterization and anticancer activities of Zn²⁺, Cu²⁺, Co²⁺ and Ni²⁺ complexes involving chiral amino alcohols†

Abstract

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Article information

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Synthesis, characterization and anticancer activities of Zn²⁺, Cu²⁺, Co²⁺ and Ni²⁺ complexes involving chiral amino alcohols

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