Issue 33, 2022, Issue in Progress
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RSC Advances

A turn-on fluorescent probe with high selectivity for Hg2+ and its applications in living cells†

Bin Li, ORCID logo a   Fuli Tian*b  and  Yupeng Huaa  

* Corresponding authors

a Department of Chemical Engineering, Ordos Institute of Technology, Ordos 017000, PR China
E-mail: ftian@imu.edu.cn

b College of Chemistry and Material Science, Hainan Vocational University of Science and Technology, Haikou 571126, P. R. China

Abstract

A novel fluorescent probe L with a rhodamine B lactam structure modified with 3-methyl-2-thiophenecarboxaldehyde has been prepared based on the thiophilicity of Hg2+. The probe L exhibits a unique response with an “off–on-type” mode towards Hg2+ among other biologically relevant metal cations. The limit of detection (LOD) for probe L is 1.5 ppb. In addition, in the presence of Hg2+, the probe L shows a colorimetric response from colorless to pink. The recognition behavior of probe L towards Hg2+ has been investigated by 1H NMR titration experiments, Job's plot, and MS and IR analyses. As a result, the ligation between the probe and Hg2+ leads to the scission of the spirolactam bond of free L and the restoration of its conjugated structure, which can give rise to the fluorescence enhancement of the probe L. Besides, it also can be used as a sensitivity probe in living cells for Hg2+ sensing, which can meet various needs in genetic and environmental samples.

Graphical abstract: A turn-on fluorescent probe with high selectivity for Hg2+ and its applications in living cells

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Article information

DOI
https://doi.org/10.1039/D2RA02185D
Article type
Paper
Submitted
05 Apr 2022
Accepted
08 Jul 2022
First published
01 Aug 2022
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2022,12, 21129-21134

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A turn-on fluorescent probe with high selectivity for Hg2+ and its applications in living cells

B. Li, F. Tian and Y. Hua, RSC Adv., 2022, 12, 21129 DOI: 10.1039/D2RA02185D

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