Issue 17, 2022
From the journal:

RSC Advances

Rhabdastrenones A–D from the sponge Rhabdastrella globostellata†

Do Thi Trang,ab   Dan Thi Thuy Hang,a   Duong Thi Dung,a   Nguyen Thi Cuc,a   Pham Hai Yen,a   Phan Thi Thanh Huong,a   Le Thi Huyen, ORCID logo c   Nguyen Thi Mai,d   Nguyen Xuan Nhiem,ab   Bui Huu Tai*ab  and  Phan Van Kiem ORCID logo *ab  

* Corresponding authors

a Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam
E-mail: bhtaiich@gmail.com, phankiem@yahoo.com

b Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam

c VNU University of Science, Vietnam National University, Hanoi, 334 Nguyen Trai, Thanh Xuan, Hanoi, Vietnam

d University of Transport and Communications, 3 Cau Giay, Dong Da, Hanoi, Vietnam

Abstract

Three new isomalabaricanes (1–3), a new α-pyrone derivative (4), together with four known isomalabaricane analogs rhabdastrellin G (5), isogeoditin A (6), stelliferin A (7), and (13E)-isogeoditin A (8) were isolated from the marine sponge Rhabdastrella globostellata. Their chemical structures were determined by HR-ESI-MS, 1D and 2D-NMR spectroscopic data analysis. The absolute configurations were identified by Mo2(OAc)4 induced ECD spectra and TD-DFT theoretical calculated ECD spectra. Compound 6 exhibited weak cytotoxic effects against HepG2 and SKMel2 cell lines with the IC50 values of 7.53 ± 0.70 and 9.93 ± 0.95 μM, respectively.

Graphical abstract: Rhabdastrenones A–D from the sponge Rhabdastrella globostellata

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Article information

DOI
https://doi.org/10.1039/D2RA01674E
Article type
Paper
Submitted
15 Mar 2022
Accepted
24 Mar 2022
First published
06 Apr 2022
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2022,12, 10646-10652

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Rhabdastrenones A–D from the sponge Rhabdastrella globostellata

D. T. Trang, D. T. T. Hang, D. T. Dung, N. T. Cuc, P. H. Yen, P. T. T. Huong, L. T. Huyen, N. T. Mai, N. X. Nhiem, B. H. Tai and P. Van Kiem, RSC Adv., 2022, 12, 10646 DOI: 10.1039/D2RA01674E

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