Issue 41, 2022

BF3·OEt2-catalyzed synthesis of 2,2′-spirobi-2H-1-benzopyrans from 2H-chromenes

Abstract

A new BF3·OEt2-catalyzed approach was developed for the construction of 2,2′-spirobi-2H-1-benzopyrancarboxylates by reacting ethyl 2-(chloromethyl)-2-hydroxy-2H-chromene-3-carboxylates with salicylaldehydes. The reactions proceeded through the formation of C–C and C–O bonds in one pot. Structure assignment of compound 3c was confirmed by single crystal X-ray analysis.

Graphical abstract: BF3·OEt2-catalyzed synthesis of 2,2′-spirobi-2H-1-benzopyrans from 2H-chromenes

Supplementary files

Article information

Article type
Paper
Submitted
18 Jul 2022
Accepted
04 Oct 2022
First published
08 Oct 2022

Org. Biomol. Chem., 2022,20, 8145-8148

BF3·OEt2-catalyzed synthesis of 2,2′-spirobi-2H-1-benzopyrans from 2H-chromenes

S. Mudulkar, S. T. Kolla, B. Sridhar and C. R. Bhimapaka, Org. Biomol. Chem., 2022, 20, 8145 DOI: 10.1039/D2OB01286C

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