Transdermal delivery of allopurinol to acute hyperuricemic mice via polymer microneedles for the regulation of serum uric acid levels

Rui Wang; Han Wang; Guohua Jiang; Yanfang Sun; Tianqi Liu; Lei Nie; Amin Shavandi; Khaydar E. Yunusov; Uladzislau E. Aharodnikau; Sergey O. Solomevich

doi:10.1039/D2BM01836E

Transdermal delivery of allopurinol to acute hyperuricemic mice via polymer microneedles for the regulation of serum uric acid levels†

Rui Wang,^a Han Wang,^b Guohua Jiang,

*^ac Yanfang Sun,*^d Tianqi Liu,^a Lei Nie,^ef Amin Shavandi,

^f Khaydar E. Yunusov,^g Uladzislau E. Aharodnikau

^h and Sergey O. Solomevich

^h

Author affiliations

* Corresponding authors

^a School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou, China
E-mail: ghjiang_cn@zstu.edu.cn

^b Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, China

^c International Scientific and Technological Cooperation Base of Intelligent Biomaterials and Functional Fibers, Hangzhou, China

^d College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, Zhejiang, China
E-mail: katherineyfs@zzstu.edu.cn

^e College of Life Science, Xinyang Normal University, Xinyang, China

^f 3BIO-BioMatter, École polytechnique de Bruxelles, Université Libre de Bruxelles (ULB), Brussels, Belgium

^g Institute of Polymer Chemistry and Physics, Uzbekistan Academy of Sciences, Tashkent, Uzbekistan

^h Research Institute for Physical Chemical Problems, Belarusian State University, Minsk, Belarus

Abstract

Allopurinol (AP) is widely used to treat hyperuricemia which may cause severe side effects upon oral administration. Alternative means for the treatment of hyperuricemia are demanded to simultaneously facilitate drug absorption, patient compliance, and fewer side effects. In this study, a new polymer microneedle (MN) system was developed for the transdermal delivery of AP to acute hyperuricemic mice. This study aims to achieve the controllable regulation of serum uric acid (SUA) levels with fewer side effects compared with oral administration. The matrix of polymer MNs consisted of polyvinylpyrrolidone (PVP) and polycaprolactone (PCL), in which the rapid dissolution of PVP offers a rapid dissolution of AP into the blood and the biodegradability of PCL resulting in a sustainable drug release behavior. An in vivo study demonstrated that the AP-loaded MN system can effectively reduce the SUA levels as oral administration with lower side effects, which will be conducive to reducing the adverse reactions and improving the bioavailability of AP. This MN-mediated strategy can facilitate transcutaneous hyperuricemia treatment and provide a new alternative for the exploration of clinical treatment of hyperuricemia and improvement of patient compliance.

This article is part of the themed collection: Microneedles

Biomaterials Science

Transdermal delivery of allopurinol to acute hyperuricemic mice via polymer microneedles for the regulation of serum uric acid levels†

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Transdermal delivery of allopurinol to acute hyperuricemic mice via polymer microneedles for the regulation of serum uric acid levels

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