Issue 15, 2021, Issue in Progress
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RSC Advances

Fluorescence imaging-guided cancer photothermal therapy using polydopamine and graphene quantum dot-capped Prussian blue nanocubes†

Meng Wang,ab   Baolong Li,a   Yu Du,c   Huimin Bu,bd   Yanyan Tanga  and  Qingli Huang ORCID logo *a  

* Corresponding authors

a Public Experimental Research Center, Xuzhou Medical University, Tong Shan No. 209, Xuzhou City, Jiangsu 221004, China
E-mail: qlhuang@xzhmu.edu.cn, qlhuang@yzu.edu.cn
Fax: +86-516-83262091

b Key Laboratory of Biotechnology for Medicinal Plants, Jiangsu Province and School of Life Sciences, Jiangsu Normal University, Xuzhou, Jiangsu 221116, China

c Medical Technology School, Xuzhou Medical University, Xuzhou, Jiangsu 221000, China

d Department of Physiology, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China

Abstract

In recent years, imaging-guided photothermal tumor ablation has attracted intense research interest as one of the most exciting strategies for cancer treatment. Herein, we prepared polydopamine and graphene quantum dot-capped Prussian blue nanocubes (PB@PDA@GQDs, PBPGs) with high photothermal conversion efficiency and excellent fluorescence performance for imaging-guided cancer treatment. Transmission electron microscopy (TEM), UV-vis absorption spectroscopy (UV-vis), fluorescence spectroscopy, and X-ray photoelectron spectroscopy (XPS) were employed to characterize their morphology and structures. The photothermal conversion efficiency and therapeutic effect were evaluated in vitro and in vivo. Results revealed that this nanoagent had excellent biocompatibility and enhanced the photothermal effect compared to blue nanocubes (PBs) and polydopamine-capped Prussian blue nanocubes (PB@PDA, PBPs). Therefore, our study may open a new path for the production of PB-based nanocomposites as theranostic nanoagents for imaging-guided photothermal cancer treatment.

Graphical abstract: Fluorescence imaging-guided cancer photothermal therapy using polydopamine and graphene quantum dot-capped Prussian blue nanocubes

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Article information

DOI
https://doi.org/10.1039/D0RA10491D
Article type
Paper
Submitted
14 Dec 2020
Accepted
05 Feb 2021
First published
24 Feb 2021
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2021,11, 8420-8429

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Fluorescence imaging-guided cancer photothermal therapy using polydopamine and graphene quantum dot-capped Prussian blue nanocubes

M. Wang, B. Li, Y. Du, H. Bu, Y. Tang and Q. Huang, RSC Adv., 2021, 11, 8420 DOI: 10.1039/D0RA10491D

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