Issue 10, 2020
From the journal:

Organic & Biomolecular Chemistry

Visible-light-promoted acyl radical cascade reaction for accessing acylated isoquinoline-1,3(2H,4H)-dione derivatives†

Yingpeng Su, ORCID logo *a   Rong Zhang,a   Wenxuan Xue, ORCID logo a   Xuan Liu,a   Yanan Zhao,a   Ke-Hu Wang,a   Danfeng Huang,a   Congde Huo ORCID logo *a  and  Yulai Hu ORCID logo *a  

* Corresponding authors

a College of Chemistry and Chemical Engineering, Northwest Normal University, 967 Anning East Road, Lanzhou 730070, P. R. China
E-mail: suyp51@nwnu.edu.cn, huocongde1978@hotmail.com, huyl@nwnu.edu.cn

Abstract

A visible-light-promoted decarboxylative acyl radical acylation/cyclization cascade reaction of N-methacryloylbenzamides for accessing acylated isoquinoline-1,3(2H,4H)-dione derivatives was described. In this report, α-keto acids were used for generating acyl radicals and inducing radical acylations. This protocol features mild reaction conditions, operational practicality and a broad substrate scope.

Graphical abstract: Visible-light-promoted acyl radical cascade reaction for accessing acylated isoquinoline-1,3(2H,4H)-dione derivatives

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Article information

DOI
https://doi.org/10.1039/D0OB00086H
Article type
Paper
Submitted
15 Jan 2020
Accepted
19 Feb 2020
First published
19 Feb 2020

Org. Biomol. Chem., 2020,18, 1940-1948

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Visible-light-promoted acyl radical cascade reaction for accessing acylated isoquinoline-1,3(2H,4H)-dione derivatives

Y. Su, R. Zhang, W. Xue, X. Liu, Y. Zhao, K. Wang, D. Huang, C. Huo and Y. Hu, Org. Biomol. Chem., 2020, 18, 1940 DOI: 10.1039/D0OB00086H

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