Issue 1, 2021
From the journal:

New Journal of Chemistry

Chelerythrine as a fluorescent light-up ligand for an i-motif DNA structure†

Hongbo Chen, ORCID logo ab   Hongxia Sun,*c   Wende Zhang,ab   Qin Zhang,ab   Jun Ma,ab   Qian Li,c   Xiaomeng Guo,c   Kanyan Xu*ab  and  Yalin Tang ORCID logo *c  

* Corresponding authors

a Shenzhou Space Biology Science and Technology Coorporation, Ltd, China Academy of Space Technology, Beijing, P. R. China
E-mail: xukanyan@cast.cn

b Space Biology Research and Technology Center, Space Biology Research and Tecchnology of China Aerospace Science and Technology Coorporation, Ltd, Beijing, P. R. China

c National Laboratory for Molecular Sciences, Center for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Institute of Chemistry Chinese Academy of Sciences, Beijing, P. R. China
E-mail: tangyl@iccas.ac.cn, hongxsun@iccas.ac.cn

Abstract

A fluorescent light-up ligand for an i-motif structure has been reported in this study. Chelerythrine (CHE) could bind to i-motif and show a significant increase in the fluorescence intensity, while exhibiting weak response towards single-stranded (ssDNA), double-stranded (dsDNA), and G-quadruplexes. This feature makes CHE advantageous in the label-free fluorescence sensing systems.

Graphical abstract: Chelerythrine as a fluorescent light-up ligand for an i-motif DNA structure

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Article information

DOI
https://doi.org/10.1039/D0NJ04863A
Article type
Communication
Submitted
03 Oct 2020
Accepted
19 Nov 2020
First published
20 Nov 2020

New J. Chem., 2021,45, 28-31

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Chelerythrine as a fluorescent light-up ligand for an i-motif DNA structure

H. Chen, H. Sun, W. Zhang, Q. Zhang, J. Ma, Q. Li, X. Guo, K. Xu and Y. Tang, New J. Chem., 2021, 45, 28 DOI: 10.1039/D0NJ04863A

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