Issue 35, 2020
From the journal:

New Journal of Chemistry

Stimuli-responsive conformational transformation of antimicrobial peptides stapled with an azobenzene unit†

Jeonghun Lee,a   Hanwool Leea  and  Chulhee Kim ORCID logo *a  

* Corresponding authors

a Department of Polymer Science and Engineering, Inha University, Incheon 22212, Korea
E-mail: chk@inha.ac.kr

Abstract

The control of the conformational transformation of KLA peptides in response to external stimuli would be an important motif to design effective peptide therapeutic agents. In this report, we investigated the stimuli-responsive conformational transformation of KLA peptide ((KLAKLAK)2 sequence) with the azobenzene stapling units in the middle of the sequence and at both the terminal moieties. The KLA peptide with an azobenzene stapling unit in the middle of the sequence exhibited a stimuli-responsive conformational transformation triggered by both UV irradiation and reductive cleavage. The KLA peptide with azobenzene stapling at both the terminals exhibited stimulus-responsive conformational transformation triggered by reductive cleavage of the azobenzene unit, but not by UV irradiation.

Graphical abstract: Stimuli-responsive conformational transformation of antimicrobial peptides stapled with an azobenzene unit

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Article information

DOI
https://doi.org/10.1039/D0NJ03409F
Article type
Letter
Submitted
07 Jul 2020
Accepted
11 Aug 2020
First published
11 Aug 2020

New J. Chem., 2020,44, 14777-14780

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Stimuli-responsive conformational transformation of antimicrobial peptides stapled with an azobenzene unit

J. Lee, H. Lee and C. Kim, New J. Chem., 2020, 44, 14777 DOI: 10.1039/D0NJ03409F

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