Issue 4, 2021
From the journal:

Chemical Communications

Synthesis of functionalized copillar[4+1]arenes and rotaxane as heteromultivalent scaffolds†

Wenzhang Chen, ORCID logo a   Tharwat Mohy EI Dinea  and  Stéphane P. Vincent ORCID logo *a  

* Corresponding authors

a Faculty of Science, University of Namur, Rue de Bruxelles, 61, Namur, Belgium
E-mail: stephane.vincent@unamur.be

Abstract

In this study, novel copillar[4+1]arenes were used as central heteromultivalent scaffolds via orthogonal couplings with a series of biologically relevant molecules such as carbohydrates, α-amino acids, biotin and phenylboronic acid. Further modifications by introducing maleimides or cyclooctyne groups provided molecular probes adapted to copper-free click chemistry. An octa-azidated fluorescent rotaxane bearing two distinct ligands was also generated in a fully controlled manner.

Graphical abstract: Synthesis of functionalized copillar[4+1]arenes and rotaxane as heteromultivalent scaffolds

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Article information

DOI
https://doi.org/10.1039/D0CC07684H
Article type
Communication
Submitted
23 Nov 2020
Accepted
03 Dec 2020
First published
08 Dec 2020

Chem. Commun., 2021,57, 492-495

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Synthesis of functionalized copillar[4+1]arenes and rotaxane as heteromultivalent scaffolds

W. Chen, T. Mohy EI Dine and S. P. Vincent, Chem. Commun., 2021, 57, 492 DOI: 10.1039/D0CC07684H

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