Issue 95, 2020

A small-sized benzothiazole–indolium fluorescent probe: the study of interaction specificity targeting c-MYC promoter G-quadruplex structures and live cell imaging

Abstract

A small-sized c-MYC promoter G-quadruplex selective fluorescent BZT-Indolium binding ligand was demonstrated for the first time as a highly target-specific and photostable probe for in vitro staining and live cell imaging and it was found to be able to inhibit the amplification of the c-MYC G-rich sequence (G-quadruplex) and down-regulate oncogene c-MYC expression in human cancer cells (HeLa).

Graphical abstract: A small-sized benzothiazole–indolium fluorescent probe: the study of interaction specificity targeting c-MYC promoter G-quadruplex structures and live cell imaging

Supplementary files

Article information

Article type
Communication
Submitted
29 Sep 2020
Accepted
25 Oct 2020
First published
04 Nov 2020

Chem. Commun., 2020,56, 15016-15019

A small-sized benzothiazole–indolium fluorescent probe: the study of interaction specificity targeting c-MYC promoter G-quadruplex structures and live cell imaging

B. Zheng, M. She, W. Long, Y. Xu, Y. Zhang, X. Huang, W. Liu, J. Hou, W. Wong and Y. Lu, Chem. Commun., 2020, 56, 15016 DOI: 10.1039/D0CC06525K

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