A redox-activatable biopolymer-based micelle for sequentially enhanced mitochondria-targeted photodynamic therapy and hypoxia-dependent chemotherapy

Yanan Li; Linawati Sutrisno; Yanhua Hou; Yang Fei; Chengcheng Xue; Yan Hu; Menghuan Li; Zhong Luo

doi:10.1039/D0CC03667F

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A redox-activatable biopolymer-based micelle for sequentially enhanced mitochondria-targeted photodynamic therapy and hypoxia-dependent chemotherapy†

Yanan Li,‡^a Linawati Sutrisno,‡^b Yanhua Hou,^c Yang Fei,^a Chengcheng Xue,^a Yan Hu,

^b Menghuan Li*^a and Zhong Luo

*^a

Author affiliations

* Corresponding authors

^a School of Life Science, Chongqing University, Chongqing 400044, China
E-mail: menghuanli@cqu.edu.cn, luozhong918@cqu.edu.cn

^b Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China

^c Chongqing Engineering Research Center of Pharmaceutical Sciences, Chongqing Medical and Pharmaceutical College, Chongqing 401331, P. R. China

Abstract

A tumor redox-activatable micellar nanoplatform based on the naturally occurring biomacromolecule hyaluronic acid (HA) was developed for complementary photodynamic/chemotherapy against CD44-positive tumors. Here HA was first conjugated with L-carnitine (Lc)-modified zinc phthalocyanine (ZnPc) via disulfide linkage and then co-assembled with tirapazamine (TPZ) to afford the physiologically stable micellar nanostructure. The mitochondria-targeted photodynamic activity of ZnPc-Lc could efficiently activate the mitochondrial apoptosis cascade and deplete the oxygen in the tumor intracellular environment to amplify the hypoxia-dependent cytotoxic effect of TPZ.

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DOI: https://doi.org/10.1039/D0CC03667F
Article type: Communication
Submitted: 23 May 2020
Accepted: 13 Jul 2020
First published: 15 Jul 2020

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Chem. Commun., 2020,56, 9978-9981

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A redox-activatable biopolymer-based micelle for sequentially enhanced mitochondria-targeted photodynamic therapy and hypoxia-dependent chemotherapy

Y. Li, L. Sutrisno, Y. Hou, Y. Fei, C. Xue, Y. Hu, M. Li and Z. Luo, Chem. Commun., 2020, 56, 9978 DOI: 10.1039/D0CC03667F

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Chemical Communications

A redox-activatable biopolymer-based micelle for sequentially enhanced mitochondria-targeted photodynamic therapy and hypoxia-dependent chemotherapy†

Abstract

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A redox-activatable biopolymer-based micelle for sequentially enhanced mitochondria-targeted photodynamic therapy and hypoxia-dependent chemotherapy

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