Issue 37, 2019
From the journal:

Journal of Materials Chemistry B

Fe@Fe3Ge2 nanoparticles for MR imaging-guided NIR-driven photodynamic therapy in vivo†

Ping Zhou,‡a   Lixing Pan,‡a   Guang Deng,a   Zhiguo Zhou, ORCID logo *a   Heng Zhao,a   Chen Peng*b  and  Shiping Yang ORCID logo *a  

* Corresponding authors

a The Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, and Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai 200234, China
E-mail: zgzhou@shnu.edu.cn, shipingy@shnu.edu.cn

b Department of Radiology, Shanghai Tenth People's Hospital, Tongji University, Shanghai 200072, China
E-mail: cpengrr@tongji.edu.cn

Abstract

Photodynamic therapy (PDT) has attracted much attention as a useful technique for disease therapy, considering its minimum invasiveness, high spatial-temporal control, and specific lesion destruction. However, the limited generation of singlet oxygen (1O2) in PDT has restricted the practical biomedical applications of photosensitizers. To overcome this issue, we first developed iron nanoparticles as an Fe nanotemplate to synthesize iron germanium nanoalloy coated iron nanoparticles (Fe@Fe3Ge2 NPs), which possess strong near-infrared (NIR) absorption, as a highly stable photosensitizer and to generate 1O2 effectively under irradiation by an 808 nm laser for NIR-PDT via the mitochondrial apoptotic pathway. Taking advantage of the strong magnetic properties of the Fe nanotemplates and the effective generation of 1O2 by Fe3Ge2 nanoshells, Fe@Fe3Ge2 NPs could be applicable for efficient targeted magnetic resonance imaging-guided NIR-PDT in an αvβ3-positive U87MG glioblastoma model. This work marks an important step forward in developing a novel nanoparticulated theranostic agent for accurate clinical cancer theranostics in the future.

Graphical abstract: Fe@Fe3Ge2 nanoparticles for MR imaging-guided NIR-driven photodynamic therapy in vivo

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Article information

DOI
https://doi.org/10.1039/C9TB01173K
Article type
Paper
Submitted
11 Jun 2019
Accepted
06 Aug 2019
First published
22 Aug 2019

J. Mater. Chem. B, 2019,7, 5661-5668

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Fe@Fe3Ge2 nanoparticles for MR imaging-guided NIR-driven photodynamic therapy in vivo

P. Zhou, L. Pan, G. Deng, Z. Zhou, H. Zhao, C. Peng and S. Yang, J. Mater. Chem. B, 2019, 7, 5661 DOI: 10.1039/C9TB01173K

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