Issue 69, 2019
From the journal:

RSC Advances

Diterpenoids from Isodon rubescens and their nitric oxide production inhibitory activity†

Chumao Wen,‡a   Su Chen,‡a   Fang Yuan,a   Xiangming Liu,a   Fajun Song,c   Zhinan Mei,b   Xiaofei Yang*a  and  Guangzhong Yang ORCID logo *b  

* Corresponding authors

a College of Biomedical Engineering, South-Central University for Nationalities, Wuhan 430074, P. R. China
E-mail: sunlittlefly@hotmail.com
Fax: +86 27 6784 1196
Tel: +86 27 6784 1196

b School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, P. R. China
E-mail: yanggz888@126.com

c College of Life Science, South Central University for Nationalities, Wuhan 430074, P. R. China

Abstract

Six new ent-kaurane diterpenoids, isodonrubescins A–F (1–6), together with twenty-five known ent-kaurane diterpenoids (7–31), a known ent-atisane diterpenoid (32), and two known ent-abietane diterpenoids (33–34), were isolated from Isodon rubescens. Their structures were established by means of extensive MS and NMR data analysis. Among the all isolates, compound 7 was found in a natural product for the first time, and ent-atisane diterpenoid was discovered from I. rubescens in Hubei Province, P. R. China for the first time. Furthermore, all the isolated compounds were tested for their NO production inhibitory activity in LPS stimulated RAW264.7 cells. Compounds 7–9, 12, 13, 16, and 17 displayed NO production inhibitory activities with IC50 values ranging from 1.36 to 18.25 μM, respectively.

Graphical abstract: Diterpenoids from Isodon rubescens and their nitric oxide production inhibitory activity

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Article information

DOI
https://doi.org/10.1039/C9RA08831H
Article type
Paper
Submitted
28 Oct 2019
Accepted
02 Dec 2019
First published
09 Dec 2019
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2019,9, 40628-40635

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Diterpenoids from Isodon rubescens and their nitric oxide production inhibitory activity

C. Wen, S. Chen, F. Yuan, X. Liu, F. Song, Z. Mei, X. Yang and G. Yang, RSC Adv., 2019, 9, 40628 DOI: 10.1039/C9RA08831H

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