Issue 57, 2019
From the journal:

RSC Advances

The antitumor activity of 4,4′-bipyridinium amphiphiles†

Senlin Wang,a   Hongshuai Wu,a   Fanghui Chen,a   Yu Zhang,a   Yuchen Zhanga  and  Baiwang Sun ORCID logo *a  

* Corresponding authors

a School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, PR China
E-mail: chmsunbw@seu.edu.cn
Fax: +86 25 52090614
Tel: +86 25 52090614

Abstract

A series of 4,4′-bipyridinium amphiphiles were synthesized and their anticancer activities were further evaluated. MTT assay showed that the cytotoxicity first increased and then decreased with the growth of carbon chains (8–16 C) at both ends of bipyridyl. Specifically, compounds with saturated carbon chains consisting of 13 carbons at both ends of bipyridyl displayed the best cell inhibitory activity with IC50 values in the low-micromolar range, which were even superior to that of cisplatin, against all the tested human cancer cells and cisplatin-resistant A549 cancer cells in vitro. In addition, compound 6 could evidently arrest the G2/M phase of the cell cycle in a dose-dependent manner. Moreover, this study demonstrates the potent performance of compound 6 in cell growth inhibition and apoptosis induction via a conceivable approach of membrane damage.

Graphical abstract: The antitumor activity of 4,4′-bipyridinium amphiphiles

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C9RA06172J
Article type
Paper
Submitted
08 Aug 2019
Accepted
26 Sep 2019
First published
16 Oct 2019
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2019,9, 33023-33028

Permissions

Request permissions

The antitumor activity of 4,4′-bipyridinium amphiphiles

S. Wang, H. Wu, F. Chen, Y. Zhang, Y. Zhang and B. Sun, RSC Adv., 2019, 9, 33023 DOI: 10.1039/C9RA06172J

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements