Issue 46, 2019, Issue in Progress
From the journal:

RSC Advances

Lipid-lowering and antioxidative effects of Apium graveolens L. root flavonoid extracts†

Yuan He, ORCID logo a   Yang Shi,b   Airong Zhang,a   Xiaoxia Zhang,a   Jing Suna  and  Li Tian ORCID logo *a  

* Corresponding authors

a College of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi, Xinjiang, China
E-mail: tianli109@126.com

b Department of Editor, Xinjiang Medical University, Urumqi, Xinjiang, China

Abstract

Flavonoids are the major components of Apium graveolens L. root (AR). In this study, we used a rat model of high-fat emulsion die induced hyperlipidemia (HLP) to examine the antioxidant and lipid-lowering effects of the AR flavonoid extract (ARFE), and to identify its potential targets by molecular docking and western-blotting. ARFE significantly lowered the serum lipid levels in HLP rats. The lipid-lowering targets of ARFE were predicted and validated, which showed that ARFE significantly downregulated the expression levels of cholesterol synthesis-associated target proteins, including SREBP1, HMGCR and ACC1. These findings demonstrate that ARFE has remarkable lipid-lowering and antioxidant effects, and the former is mediated by the inhibition of SREBP1, HMGCR and ACC1.

Graphical abstract: Lipid-lowering and antioxidative effects of Apium graveolens L. root flavonoid extracts

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Article information

DOI
https://doi.org/10.1039/C9RA04481G
Article type
Paper
Submitted
14 Jun 2019
Accepted
19 Aug 2019
First published
27 Aug 2019
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2019,9, 26757-26767

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Lipid-lowering and antioxidative effects of Apium graveolens L. root flavonoid extracts

Y. He, Y. Shi, A. Zhang, X. Zhang, J. Sun and L. Tian, RSC Adv., 2019, 9, 26757 DOI: 10.1039/C9RA04481G

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