Issue 17, 2019, Issue in Progress
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RSC Advances

Comparative study of antidiabetic, bactericidal, and antitumor activities of MEL@AgNPs, MEL@ZnONPs, and Ag–ZnO/MEL/GA nanocomposites prepared by using MEL and gum arabic

Abdelmoneim Bakur, ORCID logo ab   Tarig Elshaarani,c   Yongwu Niua  and  Qihe Chen*a  

* Corresponding authors

a Department of Food Science and Nutrition, Zhejiang University, Hangzhou 310058, China
E-mail: chenqh@zju.edu.cn

b Department of Food Sciences and Technology, University of Kordofan, El Obeid 51111, Sudan

c College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China

Abstract

In this study, a variety of nanocomposites, namely, MEL@AgNPs, MEL@ZnONPs, and Ag–ZnO/MEL/GA were biosynthesized using MEL and gum arabic to serve in biomedical applications. The synthesized nanocomposites were examined using X-ray diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM), and FTIR spectroscopy. The physicochemical properties and biomedical activities of the synthesized nanocomposites were investigated. The Ag–ZnO/MEL/GA nanocomposites showed greater antidiabetic activity against α-amylase and α-glucosidase, and higher antibacterial activity compared to MEL@AgNPs and MEL@ZnONPs. Furthermore, HepG2 cells were exposed to MEL@AgNPs, MEL@ZnONPs, and Ag–ZnO/MEL/GA nanocomposites for 24 h and their IC50 values were 63.25, 26.91 and 28.97 μg mL−1 (P < 0.05), respectively. According to this comparative study, it is apparent that the Ag–ZnO/MEL/GA nanocomposites have a great potential to serve as antitumor agents against HepG2, and antidiabetic and antibacterial agents.

Graphical abstract: Comparative study of antidiabetic, bactericidal, and antitumor activities of MEL@AgNPs, MEL@ZnONPs, and Ag–ZnO/MEL/GA nanocomposites prepared by using MEL and gum arabic

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Article information

DOI
https://doi.org/10.1039/C9RA00344D
Article type
Paper
Submitted
15 Jan 2019
Accepted
22 Mar 2019
First published
27 Mar 2019
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2019,9, 9745-9754

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Comparative study of antidiabetic, bactericidal, and antitumor activities of MEL@AgNPs, MEL@ZnONPs, and Ag–ZnO/MEL/GA nanocomposites prepared by using MEL and gum arabic

A. Bakur, T. Elshaarani, Y. Niu and Q. Chen, RSC Adv., 2019, 9, 9745 DOI: 10.1039/C9RA00344D

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