Issue 89, 2018
From the journal:

Chemical Communications

Early transition metal-catalyzed C–H alkylation: hydroaminoalkylation for Csp3–Csp3 bond formation in the synthesis of selectively substituted amines

P. M. Edwardsa  and  L. L. Schafer ORCID logo *a  

* Corresponding authors

a Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, British Columbia V6T 1Z1, Canada
E-mail: schafer@chem.ubc.ca

Abstract

Hydroaminoalkylation is a 100% atom economic method for forming Csp3–Csp3 bonds through C–H activation α to an amine and subsequent reaction with an alkene. When catalyzed by early transition metals, this reaction allows for alternative disconnections for the synthesis of structurally complex amines. This method avoids the installation of protecting groups or directing groups and does not require added oxidants, or photoredox catalysts. In this feature article, we discuss the various selectively substituted amines that can be accessed by hydroaminoalkylation, with a special focus on the development of early transition metal catalysts for their rapid, step and atom efficient assembly.

Graphical abstract: Early transition metal-catalyzed C–H alkylation: hydroaminoalkylation for Csp3–Csp3 bond formation in the synthesis of selectively substituted amines

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Article information

DOI
https://doi.org/10.1039/C8CC06445H
Article type
Feature Article
Submitted
07 Aug 2018
Accepted
14 Sep 2018
First published
18 Oct 2018

Chem. Commun., 2018,54, 12543-12560

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Early transition metal-catalyzed C–H alkylation: hydroaminoalkylation for Csp3–Csp3 bond formation in the synthesis of selectively substituted amines

P. M. Edwards and L. L. Schafer, Chem. Commun., 2018, 54, 12543 DOI: 10.1039/C8CC06445H

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