Issue 32, 2017, Issue in Progress
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RSC Advances

The relative length of dual-target conjugated on iron oxide nanoparticles plays a role in brain glioma targeting†

Penghui Ai,‡a   Hao Wang,‡c   Kang Liu,b   Tingjian Wang,a   Wei Gu,b   Ling Ye ORCID logo *b  and  Changxiang Yan*a  

* Corresponding authors

a Department of Neurosurgery, Beijing Sanbo Brain Hospital, Capital Medical University, Beijing 100093, P. R. China
E-mail: yancx65828@sina.com

b School of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, P. R. China
E-mail: lingye@ccmu.edu.cn

c Department of Anatomy, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, P. R. China

Abstract

The application of superparamagnetic iron oxide nanoparticles as a magnetic resonance (MR) nanoprobe for brain glioma is limited by the insufficient specificity and accumulation at the tumor site. To increase brain glioma-targeting specificity and improve MR contrast effect, dual-target has been employed. However, up to now, little work has been done to ascertain if the relative length of the dual-target plays a role in targeting. Herein, we prepared Cy5.5-labeled Fe3O4 NPs with chlorotoxin (CTX)/PEGylated folic acid (PEG-FA) dual-target of different relative lengths. The effect of dual-target relative length on targeting specificity was investigated by in vitro cellular uptake and in vivo MR/NIR imaging in brain glioma-bearing mice. It was demonstrated that the targeting ability of the dual-targeting Fe3O4 NPs could be modulated by adjusting the relative length of dual-target, suggesting that the relative length of dual-target plays a role in brain glioma targeting.

Graphical abstract: The relative length of dual-target conjugated on iron oxide nanoparticles plays a role in brain glioma targeting

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Article information

DOI
https://doi.org/10.1039/C7RA02102J
Article type
Paper
Submitted
20 Feb 2017
Accepted
29 Mar 2017
First published
05 Apr 2017
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2017,7, 19954-19959

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The relative length of dual-target conjugated on iron oxide nanoparticles plays a role in brain glioma targeting

P. Ai, H. Wang, K. Liu, T. Wang, W. Gu, L. Ye and C. Yan, RSC Adv., 2017, 7, 19954 DOI: 10.1039/C7RA02102J

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