Near infrared laser-controlled drug release of thermoresponsive microgel encapsulated with Fe3O4 nanoparticles
*ab
Abstract
One major issue in thermosensitive drug delivery systems is the remote, repeatable control of temperature in vivo through external stimuli such as light, ultrasound, and magnetic field. In this study, an Fe3O4/p(NIPAM-co-MAA) composite microgel (Nms) was fabricated via copolymerizing NIPAM with MAA in water-containing Fe3O4 nanoparticles modified by oleic acid. The photothermal effect and thermal-responsibility of Nms were investigated by adjusting the amount of MAA and Fe3O4 in the reaction, and the result shows an LCST of 37.2 °C, which could be elevated to 45.8 °C under laser treatment at 808 nm. In the drug release experiment, the data show that the drug can be released at an expected rate by controlling the temperature using an 808 nm laser irradiation in vivo. The release rate was fast and the final cumulative drug release rate increased by about 25%. Thus, these properties of the Fe3O4/p(NIPAM-co-MAA) Nms microgel indicate its promising application in multi-responsive microgels, especially in photothermal drug carriers.
Please wait while we load your content...
