Transition-metal-free oxidative intermolecular cyclization reaction: synthesis of 2-aryl-4-quinolones

Haojie Ma; Cui Guo; Zhenzhen Zhan; Guoqiang Lu; YiXin Zhang; Xinliang Luo; XinFeng Cui; Guosheng Huang

doi:10.1039/C7NJ01293D

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Transition-metal-free oxidative intermolecular cyclization reaction: synthesis of 2-aryl-4-quinolones†

Haojie Ma,^a Cui Guo,^b Zhenzhen Zhan,^a Guoqiang Lu,^a YiXin Zhang,^a Xinliang Luo,^a XinFeng Cui^a and Guosheng Huang

*^a

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* Corresponding authors

^a State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, Department of Chemistry, Lanzhou University, Lanzhou, P. R. China
E-mail: hgs@lzu.edu.cn

^b Yanchuan County People's Hospital, Yanchuan, P. R. China

Abstract

Herein, a novel and efficient intermolecular cyclization of 2-aminoacetophenones with aldehydes was developed for the synthesis of 2-aryl-4-quinolones through C–C and C–N bond formation. Mild conditions, good functional group tolerance, and substrates without prefunctionalization make this protocol practical, and this strategy will stimulate keen interest in fields of chemistry and biology.

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Article information

DOI: https://doi.org/10.1039/C7NJ01293D
Article type: Letter
Submitted: 18 Apr 2017
Accepted: 30 May 2017
First published: 30 May 2017

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New J. Chem., 2017,41, 5280-5283

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Transition-metal-free oxidative intermolecular cyclization reaction: synthesis of 2-aryl-4-quinolones

H. Ma, C. Guo, Z. Zhan, G. Lu, Y. Zhang, X. Luo, X. Cui and G. Huang, New J. Chem., 2017, 41, 5280 DOI: 10.1039/C7NJ01293D

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New Journal of Chemistry

Transition-metal-free oxidative intermolecular cyclization reaction: synthesis of 2-aryl-4-quinolones†

Abstract

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Transition-metal-free oxidative intermolecular cyclization reaction: synthesis of 2-aryl-4-quinolones

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