Issue 84, 2017

FeCl3-Catalyzed synthesis of pyrrolo[1,2-a]quinoxaline derivatives from 1-(2-aminophenyl)pyrroles through annulation and cleavage of cyclic ethers

Abstract

A straightforward Fe-catalyzed method for the synthesis of pyrrolo[1,2-a]quinoxalines from 1-(2-aminophenyl)pyrroles and cyclic ethers, which includes functionalization of C(sp3)-H bonds and the construction of C–C and C–N bonds, has been developed. The features of this reaction are Fe catalysis, low-cost and readily accessible starting materials. Moreover, this procedure exhibits good functional group tolerance and a series of pyrrolo[1,2-a]quinoxaline derivatives are obtained in moderate to good yields.

Graphical abstract: FeCl3-Catalyzed synthesis of pyrrolo[1,2-a]quinoxaline derivatives from 1-(2-aminophenyl)pyrroles through annulation and cleavage of cyclic ethers

Supplementary files

Article information

Article type
Communication
Submitted
11 Sep 2017
Accepted
04 Oct 2017
First published
04 Oct 2017

Chem. Commun., 2017,53, 11572-11575

FeCl3-Catalyzed synthesis of pyrrolo[1,2-a]quinoxaline derivatives from 1-(2-aminophenyl)pyrroles through annulation and cleavage of cyclic ethers

Z. An, L. Zhao, M. Wu, J. Ni, Z. Qi, G. Yu and R. Yan, Chem. Commun., 2017, 53, 11572 DOI: 10.1039/C7CC07089F

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