Issue 24, 2016

An antibacterial copper composite more bioactive than metallic silver

Abstract

Although known for its biocidal activity, copper is still not considered as a viable alternative to silver in many of its biocidal applications, mainly because it is generally considered to be a milder antibacterial metal. As copper is much cheaper than silver (1/100), it is potentially more accessible to the health and hygiene needs of third-world countries, to large volume consumer products, and to large-scale agricultural and water treatment needs. Therefore, enhancing the biocidal efficacy of copper is a sought-after goal. We report a method for achieving this goal: by entrapping molecules of the biocidal agent chlorhexidine (CH) within a metallic copper metal powder, using a new materials methodology, the antibacterial efficacy of copper towards two model nosocomial opportunistic bacteria – the Gram-negative Pseudomonas aeruginosa and the Gram-positive Staphylococcus epidermidis – is enhanced to provide a powerful antibacterial agent exceeding the activity of silver. ICP-MS elemental analysis and UV-spectroscopy indicated that the enhanced bactericidal effects of the synthesized composite, CH@Cu, are associated with the sustained release of both copper ions and CH, giving rise to synergistically enhanced activity.

Graphical abstract: An antibacterial copper composite more bioactive than metallic silver

Article information

Article type
Paper
Submitted
21 Mar 2016
Accepted
19 May 2016
First published
19 May 2016

J. Mater. Chem. B, 2016,4, 4322-4329

An antibacterial copper composite more bioactive than metallic silver

R. Ben-Knaz Wakshlak, R. Pedahzur, B. Menagen and D. Avnir, J. Mater. Chem. B, 2016, 4, 4322 DOI: 10.1039/C6TB00719H

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