Issue 6, 2016
From the journal:

New Journal of Chemistry

The p-toluenesulfonic acid catalyzed single pot synthesis of tetracyclic 1,2-dihydroquinolines: a metal free approach†

Anil K. Hajare,a   Arun R. Jagdale,a   G. Gautham Shenoyb  and  Neelima Sinha*a  

* Corresponding authors

a Novel Drug Discovery & Development, Lupin Limited, 1st Floor, Genesis Square Building, Hinjewadi, Phase-2, Village – Man, Tal. Mulshi, Dist. – Pune, Maharashtra, India

b Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka, India

Abstract

A simple, convenient and efficient p-toluenesulfonic acid catalyzed tandem reaction of aliphatic ketones with substituted anilines towards the synthesis of polysubstituted 1,2-dihydroquinolines has been developed. The ready availability of the catalyst, operational simplicity, cost effectiveness of the process and excellent regioselectivity mark some of the highlights of this methodology.

Graphical abstract: The p-toluenesulfonic acid catalyzed single pot synthesis of tetracyclic 1,2-dihydroquinolines: a metal free approach

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Article information

DOI
https://doi.org/10.1039/C6NJ00928J
Article type
Letter
Submitted
23 Mar 2016
Accepted
14 Apr 2016
First published
19 Apr 2016

New J. Chem., 2016,40, 4888-4890

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The p-toluenesulfonic acid catalyzed single pot synthesis of tetracyclic 1,2-dihydroquinolines: a metal free approach

A. K. Hajare, A. R. Jagdale, G. G. Shenoy and N. Sinha, New J. Chem., 2016, 40, 4888 DOI: 10.1039/C6NJ00928J

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