Issue 46, 2016
From the journal:

Chemical Communications

Engineering protein interfaces yields ferritin disassembly and reassembly under benign experimental conditions†

H. Chen,a   S. Zhang,a   C. Xub  and  G. Zhao*a  

* Corresponding authors

a The Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science & Nutritional Engineering, China Agricultural University, Key Laboratory of Functional Dairy, Ministry of Education, Beijing, China
E-mail: gzhao@cau.edu.cn

b School of Chinese Medicine (SCM), Chinese University of Hong Kong, Hong Kong, China

Abstract

Ferritin nanocages are promising platforms for drug encapsulation. However, extreme conditions (pH ≤ 2) required for dissociation limit their application. Here, we engineered protein interfaces to yield ferritin nanocages which disassemble at pH 4.0 and reassemble at pH 7.5. During this process, bioactive molecules can be encapsulated within the protein cavity.

Graphical abstract: Engineering protein interfaces yields ferritin disassembly and reassembly under benign experimental conditions

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Article information

DOI
https://doi.org/10.1039/C6CC03108K
Article type
Communication
Submitted
14 Apr 2016
Accepted
04 May 2016
First published
04 May 2016

Chem. Commun., 2016,52, 7402-7405

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Engineering protein interfaces yields ferritin disassembly and reassembly under benign experimental conditions

H. Chen, S. Zhang, C. Xu and G. Zhao, Chem. Commun., 2016, 52, 7402 DOI: 10.1039/C6CC03108K

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