Issue 108, 2015
From the journal:

RSC Advances

A Pd-catalyzed direct entry to 11-substituted 6H-isoindolo[2,1-a]indol-6-one derivatives as potential anticancer agents†

Suresh Babu Nallapati,ab   Raju Adepu,a   Mohd Ashraf Ashfaq,a   B. Yogi Sreenivas,a   K. Mukkantib  and  Manojit Pal*a  

* Corresponding authors

a Dr Reddy's Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad-500046, India
E-mail: manojitpal@rediffmail.com
Tel: +91 40 6657 1500

b Institute of Science and Technology, JNT University Hyderabad, Hyderabad-500085, India

Abstract

We describe Pd-mediated one-step synthesis of 11-substituted 6H-isoindolo[2,1-a]indol-6-ones via a sequential intramolecular Heck reaction of the corresponding dihalo N-allyl substituted N-arylbenzamide derivatives. Several of these compounds showed promising antiproliferative properties when tested against a number of cancer cell lines in vitro.

Graphical abstract: A Pd-catalyzed direct entry to 11-substituted 6H-isoindolo[2,1-a]indol-6-one derivatives as potential anticancer agents

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Article information

DOI
https://doi.org/10.1039/C5RA17908D
Article type
Communication
Submitted
03 Sep 2015
Accepted
13 Oct 2015
First published
13 Oct 2015

RSC Adv., 2015,5, 88686-88691

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A Pd-catalyzed direct entry to 11-substituted 6H-isoindolo[2,1-a]indol-6-one derivatives as potential anticancer agents

S. B. Nallapati, R. Adepu, M. A. Ashfaq, B. Y. Sreenivas, K. Mukkanti and M. Pal, RSC Adv., 2015, 5, 88686 DOI: 10.1039/C5RA17908D

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