Issue 104, 2015
From the journal:

RSC Advances

A novel colorimetric and near-infrared fluorescent probe for hydrogen peroxide imaging in vitro and in vivo†

Peng Wang,*a   Ke Wang,a   Dan Chen,a   Yibo Maoa  and  Yueqing Gu*a  

* Corresponding authors

a Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, 210009 Nanjing, China
E-mail: wangpeng159seu@hotmail.com

Abstract

A novel NIR fluorescent probe (DCM-B2) based on dicyanomethylene-4H-pyran was synthesized for the detection of H2O2. This colorimetric fluorescent probe displays a fluorescence turn-on response following the conversion of the aryl boronate unit to phenol in the presence of H2O2. It could offer good performance in terms of sensitivity, selectivity, and low cytotoxicity. Furthermore, bioimaging investigations indicated that this probe was cell permeable and suitable for monitoring H2O2 in vitro and in vivo.

Graphical abstract: A novel colorimetric and near-infrared fluorescent probe for hydrogen peroxide imaging in vitro and in vivo

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Article information

DOI
https://doi.org/10.1039/C5RA16827A
Article type
Paper
Submitted
20 Aug 2015
Accepted
25 Sep 2015
First published
30 Sep 2015

RSC Adv., 2015,5, 85957-85963

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A novel colorimetric and near-infrared fluorescent probe for hydrogen peroxide imaging in vitro and in vivo

P. Wang, K. Wang, D. Chen, Y. Mao and Y. Gu, RSC Adv., 2015, 5, 85957 DOI: 10.1039/C5RA16827A

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