Issue 112, 2015
From the journal:

RSC Advances

A molecular peptide beacon for IgG detection†

M. Okochi,*ab   T. Sugita,a   M. Tanakab  and  H. Hondaa  

* Corresponding authors

a Department of Biotechnology, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa, Nagoya, Aichi 464-8603, Japan
E-mail: okochi@chemeng.titech.ac.jp

b Department of Chemical Engineering, Graduate School of Science and Engineering, Tokyo Institute of Technology, 2-12-1-S1-24 O-okayama, Meguro, Tokyo 152-8552, Japan

Abstract

A molecular peptide beacon was designed for fluorescence detection of IgG in a homogeneous assay. pH-triggered detection of IgG was demonstrated using a fluorophore-labeled peptide that incorporated a binding site in the Fc region of IgG with a complementary quenching site.

Graphical abstract: A molecular peptide beacon for IgG detection

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Article information

DOI
https://doi.org/10.1039/C5RA15174K
Article type
Communication
Submitted
30 Jul 2015
Accepted
22 Oct 2015
First published
23 Oct 2015

RSC Adv., 2015,5, 91988-91992

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A molecular peptide beacon for IgG detection

M. Okochi, T. Sugita, M. Tanaka and H. Honda, RSC Adv., 2015, 5, 91988 DOI: 10.1039/C5RA15174K

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