Issue 15, 2015
From the journal:

Nanoscale

Targeting ferritin receptors for the selective delivery of imaging and therapeutic agents to breast cancer cells†

S. Geninatti Crich,*a   M. Cadenazzi,a   S. Lanzardo,a   L. Conti,a   R. Ruiu,a   D. Alberti,a   F. Cavallo,a   J. C. Cutrina  and  S. Aimea  

* Corresponding authors

a University of Turin, Department of Molecular Biotechnology and Health Sciences, via Nizza 52, Torino, Italy
E-mail: simonetta.geninatti@unito.it
Fax: +39 011 6706487
Tel: +39 011 6706473

Abstract

In this work the selective uptake of native horse spleen ferritin and apoferritin loaded with MRI contrast agents has been assessed in human breast cancer cells (MCF-7 and MDA-MB-231). The higher expression of L-ferritin receptors (SCARA5) led to an enhanced uptake in MCF-7 as shown in T2 and T1 weighted MR images, respectively. The high efficiency of ferritin internalization in MCF-7 has been exploited for the simultaneous delivery of curcumin, a natural therapeutic molecule endowed with antineoplastic and anti-inflammatory action, and the MRI contrast agent Gd-HPDO3A. This theranostic system is able to treat selectively breast cancer cells over-expressing ferritin receptors. By entrapping in apoferritin both Gd-HPDO3A and curcumin, it was possible to deliver a therapeutic dose of 167 μg ml−1 (as calculated by MRI) of this natural drug to MCF-7 cells, thus obtaining a significant reduction of cell proliferation.

Graphical abstract: Targeting ferritin receptors for the selective delivery of imaging and therapeutic agents to breast cancer cells

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Article information

DOI
https://doi.org/10.1039/C5NR00352K
Article type
Paper
Submitted
16 Jan 2015
Accepted
03 Mar 2015
First published
06 Mar 2015

Nanoscale, 2015,7, 6527-6533

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Targeting ferritin receptors for the selective delivery of imaging and therapeutic agents to breast cancer cells

S. Geninatti Crich, M. Cadenazzi, S. Lanzardo, L. Conti, R. Ruiu, D. Alberti, F. Cavallo, J. C. Cutrin and S. Aime, Nanoscale, 2015, 7, 6527 DOI: 10.1039/C5NR00352K

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