Distinct tubulin dynamics in cancer cells explored using a highly tubulin-specific fluorescent probe

Cuige Zhu; Yinglin Zuo; Baoxia Liang; Hong Yue; Xin Yue; Gesi Wen; Ruimin Wang; Junmin Quan; Jun Du; Xianzhang Bu

doi:10.1039/C5CC04927J

Distinct tubulin dynamics in cancer cells explored using a highly tubulin-specific fluorescent probe†

Cuige Zhu,^a Yinglin Zuo,^a Baoxia Liang,^a Hong Yue,^b Xin Yue,^a Gesi Wen,^a Ruimin Wang,^a Junmin Quan,^b Jun Du^a and Xianzhang Bu*^a

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* Corresponding authors

^a School of Pharmaceutical Sciences, Sun Yat-sen University, GuangZhou 510006, China
E-mail: phsbxzh@mail.sysu.edu.cn

^b Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology Peking University Shenzhen Graduate School, Shenzhen 518055, China

Abstract

A highly specific fluorescent probe (OC9) was discovered exhibiting tubulin-specific affinity fluorescence, which allowed selective labeling of cellular tubulin in microtubules. Moreover, distinct tubulin dynamics in various cellular bio-settings such as drug resistant or epithelial-mesenchymal transition (EMT) cancer cells were directly observed for the first time via OC9 staining.

Chemical Communications

Distinct tubulin dynamics in cancer cells explored using a highly tubulin-specific fluorescent probe†

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Distinct tubulin dynamics in cancer cells explored using a highly tubulin-specific fluorescent probe

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