Issue 39, 2015
From the journal:

Chemical Communications

A simple base-mediated synthesis of diverse functionalized ring-fluorinated 4H-pyrans via double direct C–F substitutions†

Jieru Yang,a   Ao Mao,a   Zhenting Yue,a   Wenxuan Zhu,a   Xuewei Luo,a   Chuwei Zhu,a   Yuanjing Xiao*a  and  Junliang Zhang*ab  

* Corresponding authors

a Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 3663 N. Zhongshan Road, Shanghai, P. R. China
E-mail: yjxiao@chem.ecnu.edu.cn, jlzhang@chem.ecnu.edu.cn

b State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, CAS. 345 Lingling Road, Shanghai, P. R. China

Abstract

A straightforward and efficient approach to structurally diverse and synthetically useful ring-fluorinated 4H-pyrans via a simple base-mediated cascade reaction of readily available trifluoromethylated alkenes with 1,3-dicarbonyl compounds was developed. The key events of this reaction involve two consecutive C–F substitutions under very mild conditions.

Graphical abstract: A simple base-mediated synthesis of diverse functionalized ring-fluorinated 4H-pyrans via double direct C–F substitutions

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Article information

DOI
https://doi.org/10.1039/C5CC02073E
Article type
Communication
Submitted
11 Mar 2015
Accepted
08 Apr 2015
First published
09 Apr 2015

Chem. Commun., 2015,51, 8326-8329

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A simple base-mediated synthesis of diverse functionalized ring-fluorinated 4H-pyrans via double direct C–F substitutions

J. Yang, A. Mao, Z. Yue, W. Zhu, X. Luo, C. Zhu, Y. Xiao and J. Zhang, Chem. Commun., 2015, 51, 8326 DOI: 10.1039/C5CC02073E

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