Issue 67, 2014
From the journal:

RSC Advances

Nucleophilic radiofluorination at room temperature via aziridinium intermediates†

M. Médocabcd  and  F. Sobrio*abcd  

* Corresponding authors

a CEA, I2BM, LDM-TEP, UMR 6301 ISTCT, GIP Cyceron, BP5229, F-14074 Caen, France
E-mail: sobrio@cyceron.fr
Fax: +33 231470275
Tel: +33 231470264

b Centre National de la Recherche Scientifique, UMR 6301 ISTCT, LDM-TEP, F-14074 Caen, France

c Université de Caen Basse-Normandie, UMR 6301 ISTCT, LDM-TEP, F-14074 Caen, France

d Normandie Univ, France

Abstract

β-[18F]fluoroamines were radiolabeled using anchimeric assistance of the amine. The ring opening of the aziridinium intermediate by different sources of nucleophilic fluoride at RT led to both fluorinated regioisomers with 18F-incorporation yields of up to 77% at RT. The radiofluorination 2-[18F]fluoroethylamines afforded single compounds from the alcohol precursor at RT.

Graphical abstract: Nucleophilic radiofluorination at room temperature via aziridinium intermediates

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Article information

DOI
https://doi.org/10.1039/C4RA07158A
Article type
Communication
Submitted
15 Jul 2014
Accepted
28 Jul 2014
First published
28 Jul 2014

RSC Adv., 2014,4, 35371-35374

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Nucleophilic radiofluorination at room temperature via aziridinium intermediates

M. Médoc and F. Sobrio, RSC Adv., 2014, 4, 35371 DOI: 10.1039/C4RA07158A

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