Issue 31, 2014
From the journal:

Organic & Biomolecular Chemistry

Synthesis of 4-alkynylquinazolines: Pd–Cu-cocatalyzed coupling of quinazoline-4-tosylates with terminal alkynes using N-heterocyclic carbenes as ligands†

Yiyuan Peng,*ab   Ping Huang,a   Yu Wang,a   Yirong Zhou,a   Jianjun Yuan,a   Qin Yang,b   Xin Jiang,a   Zhihong Denga  and  Jingshi Xua  

* Corresponding authors

a Key Laboratory of Small Functional Organic Molecule, Ministry of Education, Jiangxi's Key Laboratory of Green Chemistry and College of Life Science, Jiangxi Normal University, Nanchang, Jiangxi 330022, China
E-mail: yypeng@jxnu.edu.cn, yiyuanpeng@yahoo.com
Fax: +86-791-88120396

b CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, China

Abstract

A Pd–Cu-cocatalyzed coupling reaction of quinazoline-4-tosylates with terminal alkynes using N-heterocyclic carbenes (NHC) as ligands is described, providing 4-alkynylquinazolines in good to excellent yields. This transformation proceeds under mild conditions with high efficiency, which is attractive for focused compound library construction.

Graphical abstract: Synthesis of 4-alkynylquinazolines: Pd–Cu-cocatalyzed coupling of quinazoline-4-tosylates with terminal alkynes using N-heterocyclic carbenes as ligands

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Article information

DOI
https://doi.org/10.1039/C4OB00700J
Article type
Paper
Submitted
04 Apr 2014
Accepted
10 Jun 2014
First published
11 Jun 2014

Org. Biomol. Chem., 2014,12, 5922-5927

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Synthesis of 4-alkynylquinazolines: Pd–Cu-cocatalyzed coupling of quinazoline-4-tosylates with terminal alkynes using N-heterocyclic carbenes as ligands

Y. Peng, P. Huang, Y. Wang, Y. Zhou, J. Yuan, Q. Yang, X. Jiang, Z. Deng and J. Xu, Org. Biomol. Chem., 2014, 12, 5922 DOI: 10.1039/C4OB00700J

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