Issue 17, 2014
From the journal:

Lab on a Chip

Acoustic radiation forces at liquid interfaces impact the performance of acoustophoresis†

Sameer Deshmukh,ab   Zbigniew Brzozka,b   Thomas Laurellac  and  Per Augustsson*ad  

* Corresponding authors

a Department of Biomedical Engineering, Lund University, PO Box 118, SE-221 00 Lund, Sweden
E-mail: per.augustsson@bme.lth.se
Tel: +46 46 222 75 26

b Department of Microbioanalytics, Warsaw University of Technology, Warsaw, Poland

c Department of Biomedical Engineering, Dongguk University, Seoul, Republic of Korea

d Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA

Abstract

Acoustophoresis is a method well suited for cell and microbead separation or concentration for downstream analysis in microfluidic settings. One of the main limitations that acoustophoresis share with other microfluidic techniques is that the separation efficiency is poor for particle-rich suspensions. We report that flow laminated liquids can be relocated in a microchannel when exposed to a resonant acoustic field. Differences in acoustic impedance between two liquids cause migration of the high-impedance liquid towards an acoustic pressure node. In a set of experiments we charted this phenomenon and show herein that it can be used to either relocate liquids with respect to each other, or to stabilize the interface between them. This resulted in decreased medium carry-over when transferring microbeads (4% by volume) between suspending liquids using acoustophoresis. Furthermore we demonstrate that acoustic relocation of liquids occurs for impedance differences as low as 0.1%.

Graphical abstract: Acoustic radiation forces at liquid interfaces impact the performance of acoustophoresis

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Article information

DOI
https://doi.org/10.1039/C4LC00572D
Article type
Paper
Submitted
15 May 2014
Accepted
25 Jun 2014
First published
26 Jun 2014
This article is Open Access
Creative Commons BY-NC license

Lab Chip, 2014,14, 3394-3400

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Acoustic radiation forces at liquid interfaces impact the performance of acoustophoresis

S. Deshmukh, Z. Brzozka, T. Laurell and P. Augustsson, Lab Chip, 2014, 14, 3394 DOI: 10.1039/C4LC00572D

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