Expedient synthesis of 3-phenylbicyclo[1.1.1]pentan-1-amine via metal-free homolytic aromatic alkylation of benzene

Navanita T. Thirumoorthi; Chew Jia Shen; Vikrant A. Adsool

doi:10.1039/C4CC09655J

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Expedient synthesis of 3-phenylbicyclo[1.1.1]pentan-1-amine via metal-free homolytic aromatic alkylation of benzene†

Navanita T. Thirumoorthi,^a Chew Jia Shen^a and Vikrant A. Adsool*^a

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* Corresponding authors

^a Institute of Chemical and Engineering Sciences (ICES), Agency for Science, Technology, and Research (A*STAR), 11 Biopolis Way, Helios Block, # 03-08, Singapore 138667, Singapore
E-mail: vikrant_adsool@ices.a-star.edu.sg
Fax: +65 6874 5870
Tel: +65 6799 8503

Abstract

Recently, the potential utility of the BCP motif, as a contemporary lead optimization tactic, has generated substantial interest in medicinal chemistry. To facilitate this inquisitiveness, the concomitant development of efficient synthetic protocols is crucial. The following work discloses a new, expedient and versatile approach to one such potentially useful BCP derivative.

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Article information

DOI: https://doi.org/10.1039/C4CC09655J
Article type: Communication
Submitted: 03 Dec 2014
Accepted: 12 Jan 2015
First published: 13 Jan 2015

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Chem. Commun., 2015,51, 3139-3142

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Expedient synthesis of 3-phenylbicyclo[1.1.1]pentan-1-amine via metal-free homolytic aromatic alkylation of benzene

N. T. Thirumoorthi, C. Jia Shen and V. A. Adsool, Chem. Commun., 2015, 51, 3139 DOI: 10.1039/C4CC09655J

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Chemical Communications

Expedient synthesis of 3-phenylbicyclo[1.1.1]pentan-1-amine via metal-free homolytic aromatic alkylation of benzene†

Abstract

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Expedient synthesis of 3-phenylbicyclo[1.1.1]pentan-1-amine via metal-free homolytic aromatic alkylation of benzene

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